Pathological laughing and crying
Pathological laughing and crying (PLC) is a syndrome in which patients experience relatively uncontrollable episodes of laughing or crying, or both. The laughter or crying are provoked by nonsentimental or trivially-sentimental stimuli. These episodes not related to any manic or depression but due to a pathological illness like brain injury, stroke multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury patients, Parkinson’s as well as noncerebellar type multiple system atrophy (MSA), and 3 cerebellar type of MSA.
PLC has long been thought to result from loss of voluntary inhibition of a postulated centre for laughing and crying in the upper brainstem More recent authors have suggested that the prefrontal cortex is involved or that lesions in the cerebro-ponto-cerebellar pathways influence cerebellar structures that adjust the expression of laughter and crying.
Treatment of main disease may affect this condition but there is no cure for this disease.Some trial of tricyclic antidepressants, SSRI, AVP-923, a compound consisting of dextromethorphan and quinidine, has also shown significant therapeutic effects.
References:
- Brain 2001,124 1708-1719
- www.medhelp.org
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