ursodeoxycholic acid ……
what is the mechanism of ursodeoxycholic acid in dissolution of bile stone??
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Filed Under: Gastroenterology
what is the mechanism of ursodeoxycholic acid in dissolution of bile stone??
No related posts.
Filed Under: Gastroenterology
UDCA dissolves gallstones by solubilizing cholesterol from the stone surface. UDCA also converts supersaturated bile to unsaturated bile, and such desaturation enhances the transport capacity of bile for cholesterol. Biliary desaturation by UDCA occurs through several mechanisms, most of which are not completely understood. In addition, UDCA also has the unique property of promoting the formation of a liquid crystal mesophase of phospholipids and cholesterol. Such liquid crystals can form even in the presence of bile supersaturated with cholesterol, which may account for the observation that UDCA can dissolve gallstones in the presence of supersaturated bile.