Why there is elevated AST and ALD in grave’s disease??
Why there is elevated AST and ALD in grave’s disease??
plz explain the reason …..
No related posts.
Filed Under: Endocrine
Why there is elevated AST and ALD in grave’s disease??
plz explain the reason …..
No related posts.
Filed Under: Endocrine
Increased serum levels of AST and ALT occur in patients treated with propylthiouracil. The rise in AST appears to be dose-related, so that AST and ALT levels are highest during the first few weeks of treatment, falling rapidly with a dose reduction.And then return to normal,following withdrawal of treatment.This is the first reason if the Pt.is under anti-thyroid treatment.
And the second reason is: as we know that increase in thyroid hormone increases basal metabolic rate results in increase oxygen demand.Thus
The mechanism of injury of hepatocyes due to Graves disease appears to be relative hypoxia in the perivenular regions, due to an increase in hepatic oxygen demand without an appropriate increase in hepatic blood flow.