http://www.drknp.com/discussion/nephrogenic-diabetes-insipidus Online Medical blog Fri, 03 Sep 2010 04:34:24 +0000 hourly 1 http://wordpress.org/?v=3.0.1 http://www.drknp.com/discussion/nephrogenic-diabetes-insipidus/comment-page-1#comment-179 ukesh Sun, 17 Jan 2010 07:19:31 +0000 http://www.drknp.com/?p=552#comment-179 yes I agree with Dr.Madhu,the most widely accepted hypothesis suggests that the antidiuretic action of thiazides is secondary to increased renal sodium excretion . The renal sodium loss causes extracellular volume contraction leading to lowered GFR and increased proximal tubular sodium and water reabsorption. Hence, less water and solutes are delivered to the distal tubule and collecting duct and are lost as urine.thus by symptoms of nephrogenic DI can be controlled with Thiazide treatment. yes I agree with Dr.Madhu,the most widely accepted hypothesis suggests that the antidiuretic action of thiazides is secondary to increased renal sodium excretion . The renal sodium loss causes extracellular volume contraction leading to lowered GFR and increased proximal tubular sodium and water reabsorption. Hence, less water and solutes are delivered to the distal tubule and collecting duct and are lost as urine.thus by symptoms of nephrogenic DI can be controlled with Thiazide treatment.

]]> http://www.drknp.com/discussion/nephrogenic-diabetes-insipidus/comment-page-1#comment-172 drmadhu Fri, 15 Jan 2010 06:15:58 +0000 http://www.drknp.com/?p=552#comment-172 Thiazide can reduce urine output by inducing a state of mild volume contraction and thereby promoting increase proximal convulated tubular reabsorption of isotonic fluid and inhibiting the generation of free water. Thiazide can reduce urine output by inducing a state of mild volume contraction and thereby promoting increase proximal convulated tubular reabsorption of isotonic fluid and inhibiting the generation of free water.

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