Chronic Granulomatous Disease….
admin | Jan 17, 2010 | 2 comments
An 18 months old boy, with a high fever an cough and with a history of frequent infections, is brought to the emergency department by his father .A blood examination shows elevated numbers of neutrophils but no other defects. A blood culture for bacteria is positive .The physician sends a sample of the boy’s blood to a laboratory to test the ability of the patient’s neutrophils to produce hydrogen peroxide. The ability of this patient neutrophils to generate hydrogen peroxide e is found to be completely absent.
What cellular defect may have led to the complete absent of hydrogen peroxide generation in this patient neutrophils and how might this disease be treated using hematotherapy ?
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Filed Under: Discussion
I think he has NADPH oxidase deficiency in his PMNs which is required for conversion of O2 to H2O2…..m i rite??
i m agree with bikash.
and the answer of second question is ..normal neutrophil stem cells grown in culture may be infused to supplement the patients own defective neutorphils.